Clinical Evidence

Masimo is passionate about making innovative technologies that give clinicians the tools they need to do what is best for patient care. That’s why it is gratifying to see so many independent clinicians and clinical researchers take the time to independently evaluate our products and technologies—and then to communicate the positive impacts on patient care and safety that can be realized through their use.

More than 200 independent and objective studies by researchers around the world have demonstrated the clinical advantages of our technologies. Click on the links below to read the featured studies from all of Masimo’s technologies, or in the sections below for access by subject area to all studies.*

Featured Clinical Studies

Masimo SET^® Pulse Oximetry

Temporal quantification of oxygen saturation ranges: an effort to reduce hyperoxia in the neonatal intensive care unit M J Bizzarro, F Y Li, K Katz, V Shabanova, R A Ehrenkranz and V Bhandari. Journal of Perinatology (2014) 34, 33–38; doi:10.1038/jp.2013.122; published online 26, September 2013
Pulse oximetry with clinical assessment to screen for congenital heart disease in neonates in China: a prospective study Qu-ming Zhao, Xiao-jing Ma, Xiao-ling Ge, Fang Liu, Wei-li Yan, Lin Wu, Ming Ye, Xue-cun Liang, Jing Zhang, Yan Gao, Bing Jia, Guo-ying Huang, and the Neonatal Congenital Heart Disease screening group. Abstract online at: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2960198-7/fulltext
Performance of Three New-Generation Pulse Oximeters during Motion and Low Perfusion in Volunteers. Shah N, Ragaswamy HB, Govindugari K, Estanol L. J Clin Anesth. 2012 Aug;24(5):385-91.
Prevention of Retinopathy of Prematurity in Preterm Infants through Changes in Clinical Practice and SpO2 Technology. Castillo A., Deulofeut R., Critz A., Sola A. Acta Paediatr. 2011 Feb;100(2):188-92.
Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39,821 newborns. de-Wahl Granelli A., Wennergren M., Sandberg K., Mellander M., Bejlum C., Inganäs L., Eriksson M., Segerdahl N., Agren A., Ekman-Joelsson B.M., Sunnegårdh J., Verdicchio M., Östman-Smith I. BMJ. 2009;Jan 8;338.
More Reliable Oximetry Reduces the Frequency of Arterial Blood Gas Analyses and Hastens Oxygen Weaning after Cardiac Surgery: A Prospective, Randomized Trial of the Clinical Impact of a New Technology. Durbin C.G. Jr., Rostow S.K. Crit Care Med. 2002 Aug;30(8):1735-40.
Reliability of Conventional and New Pulse Oximetry in Neonatal Patients. Hay W.W., Rodden D.J., Collins S.M., Melara D.L., Hale K.A., Fashaw L.M. J Perinatol. 2002 Jul-Aug;22(5):360-6.
“Motion-Resistant” Pulse Oximetry: A Comparison of New and Old Models. Barker S.J. Anesth Analg. 2002 Oct;95(4):967-72.

Pleth Variability Index (PVI^®)

Pleth Variability Index-Directed Fluid Management in Abdominal Surgery under Combined General and Epidural Anesthesia Yu Y., Dong J., Xu Z., Shen H., Zheng J. J Clin Monit Comput. 2014 Feb 21.
Goal-Directed Fluid Management Based on the Pulse Oximeter-Derived Pleth Variability Index Reduces Lactate Levels and Improves Fluid Management. Forget P, Lois F, de Kock M. Anesth Analg. 2010 Oct;111(4):910-4.
Pleth Variability Index to Monitor the Respiratory Variations in the Pulse Oximeter Plethysmographic Waveform Amplitude and Predict Fluid Responsiveness in the Operating Theatre. Cannesson M., Desebbe O., Rosamel P., Delannoy B., Robin J., Bastien O., Lehot J.J. Br J Anaesth. 2008 Aug;101(2):200-6.

Masimo Patient SafetyNet^™

Impact of Pulse Oximetry Surveillance on Rescue Events and Intensive Care Unit Transfers: A Before-And-After Concurrence Study. Taenzer A.H., Pyke J.B., McGrath S.P., Blike G.T. Anesthesiology. 2010 Feb;112(2):282-7.
Postoperative Monitoring – The Dartmouth Experience. Taenzer A.H., Blike, G. T. APSF Newsletter 2012.Available at: http://www.apsf.org/newsletters/html/2012/spring/01_postop.htm Accessed June 14, 2012.
Continuous Pulse Oximetry Monitoring with Clinician Notification is Associated with Lower Patient Mortality in Post-Surgical/Medical Patients Carlson J. Respiratory Care 2013; 58 (10):1784

Total Hemoglobin (SpHb^®)

Trending and Accuracy of Noninvasive Hemoglobin Monitoring in Pediatric Perioperative Patients Patino M, Schultz L, Hossain M, Moeller J, Mahmoud M, Gunter J, Kurth CD. Anesth Analg. 2014 Jul 17. [Epub ahead of print] PubMed PMID: 25036374.
Accuracy of a Continuous Noninvasive Hemoglobin Monitor in Intensive Care Unit Patients. Frasca D., Dahyot-Fizelier C., Catherine K., Levrat Q., Debaene B., Mimoz O. Crit Care Med. 2011 Oct;39(10):2277-82.
The Accuracy of Noninvasive and Continuous Total Hemoglobin Measurement by Pulse CO-Oximetry in Human Subjects Undergoing Hemodilution. Macknet M.R., Allard M., Applegate R.L., Rook J. Anesth Analg. 2010 Dec;111(6):1424–6.

Acoustic Respiration Rate (RRa^™)

The Accuracy, Precision and Reliability of Measuring Ventilatory Rate and Detecting Ventilatory Pause by Rainbow Acoustic Monitoring and Capnometry. Ramsay M.A.E., Usman M., Lagow E., Mendoza M., Untalan E., De Vol, E. Anesth Analg 2013
Accuracy of Respiratory Rate Monitoring using a Non-Invasive Acoustic Method after General Anaesthesia. Mimoz O., Benard T., Gaucher A., Frasca D., Debaene B. Br J Anaesth. 2012 May;108(5):872-5.
Accuracy of Acoustic Respiration Rate Monitoring in Pediatric Patients Patino M., Redford D.T., Quigley T.W., Mahmoud M., Kurth C.D., Szmuk P. Paediatr Anaesth. 2013 Sep 3.

Carboxyhemoglobin (SpCO^®)

Accuracy of Noninvasive Multiwave Pulse Oximetry Compared With Carboxyhemoglobin From Blood Gas Analysis in Unselected Emergency Department Patients. Roth D., Herkner H., Schreiber W., Hubmann N., Gamper G., Laggner A.N., Havel C. Ann Emerg Med. 2011 Jul;58(1):74-9.
Noninvasive Pulse CO-Oximetry Expedites Evaluation and Management of Patients with Carbon Monoxide Poisoning. Hampson N.B. Am J Emerg Med. 2012 May 23.

Methemoglobin (SpMet^®)

Severe Methemoglobinemia Detected by Pulse Oximetry. Annabi E.H., Barker S,J. Anesth Analg. 2009;108:898–9.

SedLine^® Brain Function Monitoring

Titration of Delivery and Recovery from Propofol, Alfentanil, and Nitrous Oxide Anesthesia. Drover D.R., Lemmens H.J., Pierce E.T., Plourde G., Loyd G., Ornstein E., Prichep L.S., Chabot R.J., Gugino L. Anesthesiology 2002; 97:82–9.

Masimo Capnography and Gas Monitoring

Evaluation of a Transportable Capnometer for Monitoring End-Tidal Carbon Dioxide. Hildebrandt T., Espelund M., Olsen K.S. Anaesthesia. 2010 Oct;65(10):1017-21.

*This section is intended to provide access to independent, objective, third-party, and government-sponsored clinical studies and abstracts conducted using Masimo noninvasive technologies, parameters, and products, which are known to Masimo’s marketing department. We cannot guarantee that all clinical studies, abstracts, and research are represented. To view the individual clinical studies and abstracts, please click on the appropriate tab.

*While clinical studies and abstracts support the effectiveness of Masimo noninvasive technologies and parameters, individual results may vary. Masimo cannot guarantee specific results achieved or suggested in individual studies. Always strictly follow the directions for use (DFU) found in the product manual. Use of Masimo technologies and parameters may not be appropriate for every individual or clinical condition. Understanding the indications and limitations of use can help you make the best decision for your individual situation.

© 2013 Masimo Corporation. All rights reserved. Masimo, SET, Signal Extraction Technology, rainbow, SpHb, SpOC, SpCO, SpMet, PVI, rainbow Acoustic Monitoring, RRa, Radical-7, Rad-87, Rad-57, Rad-8, Rad-5, Pulse CO-Oximetry, Pulse CO-Oximeter, Adaptive Threshold Alarm, and SedLine are trademarks or registered trademarks of Masimo Corporation. All other product names are trademarks or registered trademarks of their respective holders.

Case Studies

from clinicians that have experienced the Masimo difference.

Acute Care Applications:

Masimo Patient SafetyNet^™

• Dead-in-bed Patient Scenario Potentially Averted: Masimo Patient SafetyNet^™ Proves to be a Critical Element for Patient Safety on General Care Floors
• Baby Escapes Deadly Distress

Pulse Oximetry (SpO2)

• Left Heart Hypoplasia: Baby Saved By Masimo SET Pulse Oximetry
• The Impact of Masimo SET Pulse Oximetry on the Reduction of ROP
• Conventional Pulse Oximetry is Unreliable During Helicopter Transport
• Erroneous SpO2 Values with Conventional Pulse Oximetry in Spite of Matched Heart and Pulse Rates could have Increased the Risk of ROP as well as Cost
• Performance of Masimo SET Pulse Oximetry in a Child with Meningococcemia

EMS/Fire Applications:

Carboxyhemoglobin (SpCO^®)

• Meridian Fire Department EMS Case Study
• Bremerton FD Case Study
• Hospital Alerted to Lethal Threat
• Detecting Carbon Monoxide Poisoning: Using advanced technology against a silent killer
• The Missed Diagnosis
• Race Against Time Prevents CO-Related Tragedy
• The Rescued Mother
• The Averted Tragedy
• The Converted Paramedic
• The Transport Decision
• The Triage Tool
• Due Diligence
• CO Poisoning in the Blood, But Not in the Air?
• Hospital Visits, Expenses & Lost Man Hours go Down When Masimo Goes In
• Charting a Lifesaving Course-of-Action
• The Great Test
• CO Intervention before Dawn Saves Lives: Masimo Rad-57 helps first responders avoid mass casualty.
• Collapse at the Marina Leads to Exhaustive Discovery
• Missed Diagnosis Leads to Emergency Intervention: Masimo Rad-57^™ Prompts Accurate CO Poisoning Diagnosis
• CO Fumes Turn a Basement into a Deadly Den: Paramedics Use the Masimo Rad-57^™ to Help Avert Disaster
• Gas Leak Wreaks Havoc in Colorado Home: The Masimo Rad-57^™ Pulse CO-Oximeter Confirms CO Poisoning in Family Members
• Narrow Escape from CO Poisoning Death… for a Second Time: Masimo Rad-57^™ Alerts Paramedics Following Missed Diagnosis One Day Earlier
• CO Gas from Forklift Sickens Building Occupants: Masimo’s Rad-57™ Convinces Reluctant Patients to Seek Treatment for CO Poisoning
• Exhaust Gas Sickens Mother and Three Children: Masimo^® Rad-57^™ Pulse CO-Oximeter^™ alerts paramedics to an unsuspected source of poisoning
• CO Screening at Local Health Fair Identifies Recurring “Mystery” Illness: Masimo Rad-57^™ Detects CO Poisoning to End Chronic Suffering
• Managing a Mass Casualty Incident with the RAD-57

Post-Acute Care Applications:

Pulse Oximetry (SpO2)

• Improving Mobility for Patients & Reducing False Alarms for Staff at a Sub-Acute Children’s Hospital
• Portability Creates Mobility for a Young Girl with Medical Challenges: Masimo Rad-5^® Gives a Teenager with Disabilities the Freedom to Dream Big

Home Care Applications:

Pulse Oximetry (SpO2)

• No Rest for the Weary: The Masimo Rad-8^® Virtually Eliminated the False Alarms
• Faulty Readings & False Alarms: Masimo Rad-8^® Provides Accuracy During Patient Motion
• Untangling Home Monitoring: The Masimo Rad-8^® Reduces Troubleshooting Calls
• Child’s Symptoms Mask Disease State & Diagnosis: Masimo Perfusion Index (PI) Helps Identify Seizure Disorder & Prompts Proper Treatment

Masimo Sponsored Webinars

Emergency Medicine

Video Case Studies

from clinicians that have experienced the Masimo difference.

Select Video:

• Reintubation – Masimo SET vs. N-200/N-290/N-295/N-3000

Technical Bulletin

• Signal Extraction Technology
• Radical SatShare^®
• Silver Standard Analysis
• Masimo Charts
• RRa^®
• Remanufactured Sensors
• Patient SafetyNet HL7

White Papers

• X-Cal™ System
• Third Party Reprocessed Sensors
• RRa
• SpCO Pulse CO-Oximetry
• Carboxyhemoglobinemia in Acute Care
• Demystifying Carboxyhemoglobinemia: Detecting Carbon Monoxide Posioning in the Emergency Department
• Rad-57 SpCO Accuracy
• Demystifying Methemoglobinemia: A Clinically Pervasive Disorder with Ambiguous Symptoms Masking Prevalence, Morbidity, and Mortality
• Emerging Uses of Capnometry in Emergency Medicine
• General Floor Monitoring
• Patient SafetyNet™ and ROI Worksheet
• Advanced Alarm Management
• GE Alarm Management
• Pulse Oximetry Accuracy
• Verification of SpO2 Values
• APOD^®, Adaptive Probe-Off Detection
• FastSat^®
• Signal IQ
• SatSeconds
• Plethysmographic
• Perfusion Index
• Masimo Low Perfusion Performance
• Measurement during very low perfusion
• Measurement during very low Cardiac Output
• Datex-Ohmeda